Hope for finding the cause of ongoing diarrhea

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Now There's a Test

Now there's a test for many common causes all at once1-6,*

Having an upset stomach for a night or 2 is pretty common.1 But ongoing diarrhea lasting more than 2 weeks is known as persistent diarrhea.7-8 It can be a sign of a more serious gastrointestinal (GI) condition that may need specific treatment.8

Finding the cause(s) of persistent diarrhea is not easy, so it could be a slow and sometimes frustrating process.1,2,7,9 Often this process requires a series of tests that can take weeks, or perhaps even months, to complete.1,2,9

With the PROMETHEUS® IBcause™ Diagnostic Test, your doctor can help you get answers with a stool and blood test that may speed up the current step-by-step testing process. The sooner you know the answers, the sooner your doctor can determine a treatment plan.

IBcause™. Because you and your doctor want to know.

*Assays can also be ordered separately and all results should be used in combination with other clinical findings.


About Persistent Diarrhea

persistent diarrhea

What is it?

Ongoing diarrhea. It can be frustrating and very inconvenient. Fortunately, diarrhea usually lasts for only hours, or sometimes days. But if lasts more than 2 weeks, it’s not just diarrhea anymore. Known as persistent diarrhea, it could be caused by a more serious underlying condition.7,10 The sooner you find the answers, the sooner your doctor can determine a treatment plan.

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About IBcause

About IBcause

Stool-and-blood test to help diagnose common underlying causes of persistent diarrhea

IBcause™ helps doctors diagnose common underlying causes of persistent diarrhea, including fecal gastrointestinal (GI) pathogens (eg, bacteria, viruses, and parasites), intestinal inflammation associated with inflammatory bowel disease (IBD), bile acid malabsorption, irritable bowel syndrome (IBS), and celiac disease.1-6

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Collect Your Sample

Stool collection made simple

Everything you need is provided

Prometheus has created a convenient kit, along with step-by-step instructions, to make it easy to collect your stool sample.

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Helpful Tips

Helpful tips and tools

You don't have to deal with persistent diarrhea on your own

The more you know, the better. Use these resources to gain more information, help you talk to your doctor about IBcause, and learn about available support services.

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Prometheus Online

The Prometheus Online portal

Sign up or sign in

The Prometheus Online portal provides a convenient place to view useful information about the IBcause™ test your doctor has ordered.

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  1. 1.DuPont HL. Persistent diarrhea: a clinical review. JAMA. 2016;315(24):2712-2723.

  2. 2.Juckett G, Trivedi R. Evaluation of chronic diarrhea. Am Fam Physician. 2011;84(10):1119-1126.

  3. 3.Gujral N, Freeman HJ, Thomson AB. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol. 2012;18(42):6036-6059.

  4. 4.Hodges K, Gill R. Infectious diarrhea: cellular and molecular mechanisms. Gut Microbes. 2010;1(1):4-21.

  5. 5.Spiller R, Lam C. An update on post-infectious irritable bowel syndrome: role of genetics, immune activation, serotonin and altered microbiome. J Neurogastroenterol Motil. 2012;18(3):258-268.

  6. 6.Barkun AN, Love J, Gould M, Pluta H, Steinhart H. Bile acid malabsorption in chronic diarrhea: pathophysiology and treatment. Can J Gastroenterol. 2013;27(11):653-659.

  7. 7.Navaneethan U, Giannella RA. Definition, epidemiology, pathophysiology, clinical classification, and differential diagnosis of diarrhea. In: Guandalini S, Vaziri H, eds. Diarrhea: Diagnostic and Therapeutic Advances. New York, NY: Humana Press; 2011:1-31.

  8. 8.Hygiene-related diseases. Centers for Disease Control and Prevention Web site. https://www.cdc.gov/healthywater/hygiene/disease/chronic_diarrhea.html. Updated August 18, 2011. Accessed January 18, 2017.

  9. 9.Fine KD, Schiller LR. AGA technical review on the evaluation and management of chronic diarrhea. Gastroenterology. 1999;116(6):1464-1486.

  10. 10.Diarrhea. Cleveland Clinic Web site. http://my.clevelandclinic.org/health/articles/diarrhea. Last reviewed August 15, 2016. Accessed January 18, 2017.