Test to uncover many troublemakers all at 1 time*

A convenient all-in-one stool and serum test to help diagnose common underlying causes of persistent diarrhea1-6


It’s often challenging when patients present with persistent diarrhea because there are so many potential causes that may warrant examination.2,7 But what if you could get to a diagnosis faster and a specific treatment plan sooner?**

The PROMETHEUS® IBcause™ Diagnostic Test may help make it possible. IBcause™ can help you determine what’s irritating the bowel and causing persistent diarrhea.

What’s different about IBcause?

Now you can evaluate a unique combination of 20 stool and serum measures all at 1 time. IBcause™ helps uncover potential causes of persistent diarrhea, including intestinal inflammation, irritable bowel syndrome (IBS), multiple pathogens, celiac disease, and bile acid malabsorption (BAM).1-6

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1 convenient test. Many key assays

By bringing multiple stool and serum assays together, IBcause™ quickly helps identify both infectious and noninfectious potential causes of persistent diarrhea. And, for added convenience, you don’t have to order multiple separate tests.

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Clear & concise results

All IBcause™ test results are conveniently summarized in an easy-to-read 1-page report. It avoids having to sort through pages and pages of data.

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  All in one. All at once.*

*Assays can also be ordered separately, and all results should be used in combination with other clinical findings.

**Compared to sequential testing with standard workup for persistent diarrhea.



  1. 1.DuPont HL. Persistent diarrhea: a clinical review. JAMA. 2016;315(24):2712-2723.

  2. 2.Juckett G, Trivedi R. Evaluation of chronic diarrhea. Am Fam Physician. 2011;84(10):1119-1126.

  3. 3.Gujral N, Freeman HJ, Thomson AB. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol. 2012;18(42):6036-6059.

  4. 4.Hodges K, Gill R. Infectious diarrhea: cellular and molecular mechanisms. Gut Microbes. 2010;1(1):4-21.

  5. 5.Spiller R, Lam C. An update on post-infectious irritable bowel syndrome: role of genetics, immune activation, serotonin and altered microbiome. J Neurogastroenterol Motil. 2012;18(3):258-268.

  6. 6.Barkun AN, Love J, Gould M, Pluta H, Steinhart H. Bile acid malabsorption in chronic diarrhea: pathophysiology and treatment. Can J Gastroenterol. 2013;27(11):653-659.

  7. 7.Navaneethan U, Giannella RA. Definition, epidemiology, pathophysiology, clinical classification, and differential diagnosis of diarrhea. In: Guandalini S, Vaziri H, eds. Diarrhea: Diagnostic and Therapeutic Advances. New York, NY: Humana Press; 2011:1-31.