You want to determine the underlying cause of a patient’s persistent diarrhea as quickly as you can. But have you ever considered that the limitations of current diagnostic pathways (eg, sequential testing and empiric treatment) may be slowing you down?1,2,7

Now there is a test that may help you get to a diagnosis faster.* The PROMETHEUS® IBcause™ Diagnostic Test allows you to conveniently evaluate a unique combination of 20 stool and serum measures all at 1 time.

How it compares

Compared to sequential testing and empiric treatment, IBcause™ may:

Patentedcooling systemdesigned to preserve stool integrity for optimal test outcomes

  • Speed the conventional diagnostic pathway
  • Provide a more complete view

IBcause™ also helps you identify a multifactorial GI condition that could currently go unrecognized with sequential testing or empiric treatment.1 This is an important feature considering that it is not uncommon for patients to have more than 1 potentially causative factor for persistent diarrhea.8

Makes stool collection easy

With IBcause, your patients receive 1 package with everything they need to perform a sanitary stool collection in the privacy of their home. It is designed to improve compliance, which can be difficult for patients with diarrhea.9

A patented NanoCool® shipping pack is designed to keep the patient’s stool sample cold to preserve integrity for optimal test outcomes. We even provide a prepaid return label to make shipping as effortless as possible for your patients.

We also provide:

  • Step-by-step instructions (for both stool collection and serum draw) for patients
  • Telephone support to answer all patient questions
  • Support for you and your office, including a dedicated portal (PrometheusOnline.com) to order IBcause™ online

Patentedcooling systemdesigned to preserve stool integrity for optimal test outcomes

One convenient test for your persistent diarrhea patients

Order IBcause™ for:

  • New patients who present with persistent diarrhea and have not had prior testing done
  • Patients who have had some initial or inconclusive testing (assays may be ordered separately)**
IBcause. Because you want to know what may be irritating the bowel and causing your patients’ persistent diarrhea.

  All in one. All at once.**

*Compared to sequential testing with standard workup for persistent diarrhea.

**Assays can also be ordered separately, and all results should be used in combination with other clinical findings.


  1. 1.DuPont HL. Persistent diarrhea: a clinical review. JAMA. 2016;315(24):2712-2723.

  2. 2.Juckett G, Trivedi R. Evaluation of chronic diarrhea. Am Fam Physician. 2011;84(10):1119-1126.

  3. 3.Gujral N, Freeman HJ, Thomson AB. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol. 2012;18(42):6036-6059.

  4. 4.Hodges K, Gill R. Infectious diarrhea: cellular and molecular mechanisms. Gut Microbes. 2010;1(1):4-21.

  5. 5.Spiller R, Lam C. An update on post-infectious irritable bowel syndrome: role of genetics, immune activation, serotonin and altered microbiome. J Neurogastroenterol Motil. 2012;18(3):258-268.

  6. 6.Barkun AN, Love J, Gould M, Pluta H, Steinhart H. Bile acid malabsorption in chronic diarrhea: pathophysiology and treatment. Can J Gastroenterol. 2013;27(11):653-659.

  7. 7.Fine KD, Schiller LR. AGA technical review on the evaluation and management of chronic diarrhea. Gastroenterology. 1999;116(6):1464-1686.

  8. 8.Data on file, Prometheus Laboratories Inc.

  9. 9.Lecky DM, Hawking MK, McNulty CA; ESBL steering group. Patients’ perspectives on providing a stool sample to their GP: a qualitative study. Br J Gen Pract. 2014;64(628):e684-e693.