Q: What is IBcause™?  

A: IBcause™ is a stool and serum test that conveniently helps to diagnose many common underlying causes of persistent diarrhea, including intestinal inflammation, celiac disease, irritable bowel syndrome (IBS), multiple pathogens, and bile acid malabsorption (BAM).1-6

Q: Why is IBcause™ so convenient?  

A: With IBcause, you are able to evaluate a unique combination of 20 stool and serum measures all at 1 time. IBcause™ may help you get to a diagnosis faster and a specific treatment plan sooner than you would from sequential testing with the standard workup for persistent diarrhea. And you only have to order IBcause; you don’t have to order multiple tests.

Q: How many pathogens does IBcause™ test for?  

A: IBcause™ tests for multiple pathogens that may be present concurrently, including 8 types of bacteria, 3 types of parasites, and 3 types of viruses.1,7 It rules out > 90% of acute diarrhea-causing agents.8

Q: What other assays are included in IBcause?  

A: IBcause™ tests for fecal calprotectin, a well-known predictor of inflammation associated with inflammatory bowel disease (IBD).9 It also includes an assay for 7α-hydroxy-4-cholesten-3-one (7C4).10

IBcause™ offers highly sensitive and specific diagnostic serological assays for celiac disease, including: anti-endomysial lgA (EMA IgA), anti-human tissue transglutaminase lgA (tTG IgA), and total serum IgA (which addresses the needs of patients who may test negative for celiac disease due to IgA deficiency).11

IBcause™ also evaluates high-sensitivity C-reactive protein (hsCRP) to help determine the likelihood of mucosal inflammatory conditions, such as IBD and infection.

Q: How do I order IBcause?  

A: You can order IBcause™ tests by creating an account at PrometheusOnline.com.

Q: Can I order any of the IBcause™ assays separately?  

A: Yes. All IBcause™ assays can also be ordered separately. Of course, all results should be used in combination with other clinical findings.

Q: Why should I create a PrometheusOnline.com portal account?  

A: At PrometheusOnline.com you can order IBcause™ tests, and you will be notified when patient test results are posted to your account.

Q: Whom do I call if I have any technical issues with my PrometheusOnline.com portal account?  

A: If you experience any technical issues with the PrometheusOnline.com portal, call Prometheus Client Services at 888-423-5227, Option 1.

Q: How quickly will I receive a patient’s IBcause™ test results?  

A: You will receive a patient’s IBcause™ test results about 1 week after the sample is received by Prometheus Laboratories.

Q: Whom can I call if my practice has any questions about IBcause™ test results?  

A: If you have any questions about a patient’s test results, call Prometheus Client Services at 888-423-5227, Option 1 or contact us online.

Q: Will I see my patient’s test result before he/she does?  

A: Yes. IBcause™ test results are always sent to you first, so you can discuss them with your patients. Then you can allow patients to access their test results online once they create an account at PrometheusOnline.com.

Q: How do I provide my patients with an IBcause™ Stool Collection kit?  

A: You can order IBcause™ Stool Collection kits and have them sent directly to your patients by creating an account at PrometheusOnline.com. You can also call Prometheus Client Services at 888-423-5227, Option 1.

Q: What if my patients have questions about collecting their stool sample?  

A: If patients have any questions, they can call Prometheus Client Services directly at 888-423-5227, Option 1. Patients will receive specific instructions for both serum draw and stool collection. Everything your patient needs is provided, including a guide, videos, and a website specifically for patients. Patients can also get information if they create a patient account at PrometheusOnline.com.

Q: Can patients provide a loose stool sample?  

A: Yes, it is actually preferable for patients to collect a loose stool sample. Since loose stools are common with any type of diarrhea, this should not be difficult for your patients. However, patients should not collect a very watery (all liquid) stool sample.

Have more questions? Contact us  

IBcause. Because you want to know what may be irritating the bowel and causing your patients’ persistent diarrhea.

  All in one. All at once.*

*Assays can also be ordered separately, and all results should be used in combination with other clinical findings.


  1. 1.DuPont HL. Persistent diarrhea: a clinical review. JAMA. 2016;315(24):2712-2723.

  2. 2.Juckett G, Trivedi R. Evaluation of chronic diarrhea. Am Fam Physician. 2011;84(10):1119-1126.

  3. 3.Gujral N, Freeman HJ, Thomson AB. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol. 2012;18(42):6036-6059.

  4. 4.Hodges K, Gill R. Infectious diarrhea: cellular and molecular mechanisms. Gut Microbes. 2010;1(1):4-21.

  5. 5.Spiller R, Lam C. An update on post-infectious irritable bowel syndrome: role of genetics, immune activation, serotonin and altered microbiome. J Neurogastroenterol Motil. 2012;18(3):258-268.

  6. 6.Barkun AN, Love J, Gould M, Pluta H, Steinhart H. Bile acid malabsorption in chronic diarrhea: pathophysiology and treatment. Can J Gastroenterol. 2013;27(11):653-659.

  7. 7.Luminex [package insert]. Toronto, ON, Canada: Luminex Molecular Diagnostics, Inc.; 2014.

  8. 8.Luminex Corporation. xTAG® Gastrointestinal Pathogen Panel (GPP). 2014.

  9. 9.Benítez JM, García-Sánchez V. Faecal calprotectin: management in inflammatory bowel disease. World J Gastrointest Pathophysiol. 2015;15;6(4):203-209.

  10. 10.Camilleri M. Bile acid diarrhea: prevalence, pathogenesis, and therapy. Gut Liver. 2015;9(3):332-339.

  11. 11.Presutti RJ, Cangemi JR, Cassidy HD, Hill DA. Celiac disease. Am Fam Physician. 2007;76(12):1795-1802.