Test to uncover many troublemakers all at 1 time*

A convenient all-in-one stool and serum test to help diagnose common underlying causes of persistent diarrhea1-6


It’s often challenging when patients present with persistent diarrhea because there are so many potential causes that may warrant examination.2,7 But what if you could get to a diagnosis faster and a specific treatment plan sooner?**

The PROMETHEUS® IBcause™ Diagnostic Test may help make it possible. IBcause™ can help you determine what’s irritating the bowel and causing persistent diarrhea.

What’s different about IBcause?

Now you can evaluate a unique combination of 20 stool and serum measures all at 1 time. IBcause helps uncover potential causes of persistent diarrhea, including intestinal inflammation, irritable bowel syndrome (IBS), multiple pathogens, celiac disease, and bile acid malabsorption (BAM).1-6

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1 convenient test. Many key assays

By bringing multiple stool and serum assays together, IBcause quickly helps identify both infectious and noninfectious potential causes of persistent diarrhea. And, for added convenience, you don’t have to order multiple separate tests.

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Clear & concise results

All IBcause test results are conveniently summarized in an easy-to-read 1-page report. It avoids having to sort through pages and pages of data.

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  All in one. All at once.*

*Assays can also be ordered separately, and all results should be used in combination with other clinical findings.

**Compared to sequential testing with standard workup for persistent diarrhea.



  1. 1.DuPont HL. Persistent diarrhea: a clinical review. JAMA. 2016;315(24):2712-2723.

  2. 2.Juckett G, Trivedi R. Evaluation of chronic diarrhea. Am Fam Physician. 2011;84(10):1119-1126.

  3. 3.Gujral N, Freeman HJ, Thomson AB. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol. 2012;18(42):6036-6059.

  4. 4.Hodges K, Gill R. Infectious diarrhea: cellular and molecular mechanisms. Gut Microbes. 2010;1(1):4-21.

  5. 5.Spiller R, Lam C. An update on post-infectious irritable bowel syndrome: role of genetics, immune activation, serotonin and altered microbiome. J Neurogastroenterol Motil. 2012;18(3):258-268.

  6. 6.Barkun AN, Love J, Gould M, Pluta H, Steinhart H. Bile acid malabsorption in chronic diarrhea: pathophysiology and treatment. Can J Gastroenterol. 2013;27(11):653-659.

  7. 7.Navaneethan U, Giannella RA. Definition, epidemiology, pathophysiology, clinical classification, and differential diagnosis of diarrhea. In: Guandalini S, Vaziri H, eds. Diarrhea: Diagnostic and Therapeutic Advances. New York, NY: Humana Press; 2011:1-31.